Kei Kamara is tied with Sebastian Giovinco for the MLS goal lead, but the Crew striker is unavailable this weekend due to yellow card accumulation.
Orlando City continues to fight for a playoff spot, but they'll face off against New York City FC this weekend without Kaka, who is suspended for the match.
Kaka has missed two games recently due to injury, but he could return to face the Red Bulls on Friday. RotoWire's D.J. Trainor breaks down all the MLS injury news heading into the weekend.
With a lot of players away for international duty, a few new names sneak into the weekly rankings, though Obafemi Martins is still around to claim the top forward spot.
RotoWire's JD Bazzo thinks Obafemi Martins is one of the top plays this weekend, and he has a few different ways to comfortably get the Sounders attacker into DraftKings lineups with some other upper-tier players.
David Villa has six goals in his last four games and will next face off against a Montreal side he's burned for three goals and one assist in two previous meetings.
David Villa is high up on the goal expectancy projection for Week 22, though there are a few players with better chances.
Major League Soccer's leading goal scorer, Kei Kamara, has a great matchup this weekend against a Chicago side that he scored against just days ago.
A few big name players are out with injuries, while the Gold Cup has taken a few more top stars like Toronto's Jozy Altidore.
Despite a number of star players unavailable because of the Gold Cup, there is still plenty of firepower in MLS this weekend, headlined by the Galaxy's Robbie Keane.
The Columbus Crew were off last weekend, but they are back to face the Revolution on Wednesday and will be led by Kei Kamara.
The form table appears to be upside down, as Kei Kamara and the Columbus Crew find themselves with the fewest points in all of Major League Soccer in their last six games.
MLS is back with a fuller slate of games, and if Toronto FC is playing, then Sebastian Giovinco is going to be near the top of the rankings.
A short slate and international competitions reduces the player pool, but a few familiar faces are still near the top of the rankings this week.