Christian Benteke has been ruled out for the entire holiday period due to the knee injury he's been playing through over the past month.
Sergio Aguero is expected to miss at least a month due to the calf injury he suffered in last weekend's tilt with Arsenal.
Robin van Persie was a surprise member of Manchester United's starting XI last week, but suffered an injury in the Champions League on Tuesday and will now be out a month.
Robin van Persie has missed four games in a row and doesn't appear ready for this weekend's match against Newcastle.