Christian Eriksen has been a dynamic part of the Spurs midfield, and he'll be needed in a big way Saturday against Manchester City at the Etihad.
Sadio Mane has been in red hot form of late, and Ajay Patil is expecting it to continue Sunday against Chelsea at Anfield.
Gylfi Sigurdsson and Lucas Digne get most of the fantasy attention from Everton, but fantasy players shouldn't forget about Richarlison when the Toffees travel to face Fulham.
Lionel Messi has been nearly unstoppable this season, but he'll face a tough task Saturday against Atletico Madrid.
Real Madrid are heavy favorites against Huesca, and there's plenty of optimism that Karim Benzema will have a big impact.
Liverpool have a tough matchup against Tottenham on Sunday, but Sadio Mane has shown time and again that he can have an impact against anyone.
Atletico Madrid continue to fight for the top of La Liga, and they'll need a solid performance from Antoine Griezmann on Saturday against Alaves.
Manchester City is expected to throttle Fulham on Saturday, with plenty of reason to think Sergio Aguero will play a big part.
Lyon will look to avenge their previous loss to Rennes, and they'll need Nabil Fekir to step up if they want to have a chance.
Hoffenheim take on Bayer Leverkusen in a match with significant top-six implications, with the home side likely needing an impact from Joelinton.
Portugal disappointed in their Euro 2020 qualification opener last week, and they'll have a tough task bouncing back against Serbia.
Kylian Mbappe has been unstoppable this season, and there's little reason to think Iceland will be able to shut him down in their Euro 2020 qualifier.
Germany are in a bit of transition as they open their Euro 2020 qualification campaign against the Netherlands, but they'll likely continue to rely on Marco Reus to make an impact.
Wales will be without Aaron Ramsey for their Euro 2020 qualifier against Slovakia, putting more pressure on the shoulders of Gareth Bale.
Sweden host Romania in their first Euro 2020 qualifying match Saturday, and they will need Emil Forsberg to step up.
Spain are heavily favored at home against Norway in their opening Euro 2020 qualifier, with La Roja expecting another solid performance from Sergio Ramos.
Cristiano Ronaldo is finally back with the Portugal squad, and he's expected to make a big impact at home against Ukraine.
Belgium kick off their Euro 2020 qualification against Russia on Thursday, and Ajay Patil is expecting a big performance from Eden Hazard.
Kylian Mbappe has been absolutely dominant during Ligue 1 play this season, and Marseille will surely have their hands full trying to slow him down Sunday.
There is no denying Lionel Messi will be expected to make an impact Sunday against Betis, but Azeem Siddiqui sees a number of other key players who can contribute.
Eden Hazard has struggled of late, but Chelsea will need him to step up if they are to get a result at Goodison Park on Sunday.
Given Mohamed Salah's struggles lately and his own excellent form, Ajay Patil is giving the captain's armband to Sadio Mane on Sunday.
Cristiano Ronaldo bagged a hat trick earlier this week against Atletico Madrid in the Champions League, and he'll look to extend his fine form Sunday against Genoa.
A new era at Real Madrid begins this weekend, as Karim Benzema will hope to star in Zinedine Zidane's return to the touchline.
Liverpool are flying after Wednesday's Champions League win over Bayern Munich in Germany, but does RotoWire's Chris Owen think fantasy players can get back to trusting Mohamed Salah?
Real Sociedad face off against Levante on Friday, and Azeem Siddiqui breaks it down for the Dream11 slate.
Federico Chiesa hasn't scored in his last six Serie A starts, but he continues to take plenty of shots and has a decent chance to score Friday against Cagliari.
The two highest-scoring teams in the Premier League, who also happen to be the two who have conceded the fewest goals, will face off in a huge match Thursday that could be a major factor in who wins the Premier League this season.
Chelsea are the biggest favorite on Wednesday's six-game slate, with the oddsmakers expecting them to win comfortably at home against Southampton.
Arsenal are big favorites at home against Fulham on New Year's Day, which could have fantasy players targeting Alexandre Lacazette, if he starts.